1. MAHFUZAH - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
2. RISKIANA DJAMIN - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
3. ANDI BASO SULAIMAN - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
4. MUHAMMAD AMSYAR AKIL - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
5. TRINING DYAH - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
6. ABDUL QADAR PUNAGI - Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University,
Makassar, South Sulawesi, Indonesia.
7. ARIFIN SEWENG - Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Bacterial infection is the dominant factor in most cases of otitis media. The middle ear mucosa acts as the main barrier to pathology, innate immunity plays a key role in maintaining protection against pathogenic bacteria, one of which is by activating toll-like receptors-2 (TLR2). The aim of this study was to compare TLR2 expression in chronic suppurative otitis media (CSOM) with and without cholesteatoma. This research method is analytic observational with cross sectional approach. The total sample was 55 samples, 38 samples of middle ear secretions (12 samples in the CSOM group with cholesteatoma and 26 samples in the CSOM group without cholesteatoma), and 17 samples of the middle ear mucosa (4 samples in the CSOM group with cholesteatoma and 13 in the CSOM group without cholesteatoma). .TLR2 expression was measured by ELISA method. The results showed that the expression of TLR2 in samples of middle ear secretions was not significantly different (p=0.180), TLR2 expression in samples of middle ear mucosa was not significantly different (p=0.395), TLR2 expression in samples of middle ear secretions and middle ear mucosa was not significantly different in CSOM with and without cholesteatoma (p=0.332, p=0.412). So it can be concluded that there is no difference in TLR2 expression in CSOM with and without cholesteatoma, these findings indicate that TLR2 plays the same role in both groups.
Chronic suppurative otitis media, cholesteatoma, toll-like receptors-2.