Due to their deeply ingrained beliefs, many communities throughout the world include Allium ascalonicum (AAS) in their diets. Earlier reports on AAS extracts proves its anticancer and antibacterial efficiency. Current research focused the Phytochemical Screening through GCMS and Pharmacological Evaluation of Alliumas Ascalonicum. The AAS plant was collected from to Waziristan and Bannu, KP Pakistan, in September 2019 and confirmed by Faculty of Pharmacy, Gomal University DI Khan, Pak. The aerial components of the AAS were collected and sliced into small parts and extracts in various solvents along with crude drug were prepared. Various compounds were identified using GCMS screening and 35 compounds were screened. The activities, antioxidant assay, urease assay, and anticholinesterase assay were carried out with crude (Cr), fixed oil, ethyl acetate (EtAc), chloroform (Chf), hexane (Hex), and aqueous (Aq) extracts. Significant results were obtained with EtAc, and fixed oil for these activities. The screened compounds and marked pharmacological activities make AAS as one of the most significant medicinal dietary plants to be further evaluated for clinical utilization. The current research gives an outlook for the future evaluation of AAS and AAS derived compounds including its fixed oils against various pharmacological uses.