The causative agent of COVID - 19 coronavirus infection is the new SARS-CoV-2 virus. In March 2020, the World Health Organization announced a pandemic of coronavirus infection (SARS-CoV-2). By mid-March 2021, 119 million people worldwide had contracted this infection, 94.7 million had recovered and 2.6 million had died. In Kazakhstan, 1.39 million people fell ill with this infection, 1.29 million people recovered, and 19 thousand people died. Premature birth is more common in pregnant women with pneumonia, premature babies with low body weight are born, and the frequency of cesarean sections is high. Materials and Methods: Clinical observations and studies were carried out in the period from April 2020 to May 2022 for pregnant and postpartum women in the "City Infectious Diseases Hospital"(Symkent, Kazkhstan), "Perinatal centers" of the Turkestan region and the cities of Shymkent. In order to implement the 1st stage of the study, a total of 120 pregnant women were subjected to comprehensive examinations. Results: For complicated forms of COVID-19 in pregnant women, primary clinical signs are characteristic (in order of differentiation) compared to mild forms: shortness of breath (82.1%), unproductive cough (83.4%), hemorrhagic syndrome (20%), and myalgia (44.6%) (p<0.05). La-borator criteria for severe course of COVID-19 in pregnant women are: anemia (77.8%), leukopenia (21.4%) or leukocytosis (27.1%), thrombocytopenia (24.2%), hypercoagulation (29.2%), increased AST activity (34.2%), increased CFC (7.8%) (p<0.05). The most important factors of maternal mortality in COVID-19 are: late seeking medical help and etiotropic therapy. Conclusion: Pregnant women with pandemic flu are at risk of premature birth, regardless of the severity of COVID-19 and gestational age with the flu. A characteristic complication of childbirth in patients with influenza in the III trimester of pregnancy is untimely discharge of amniotic fluid.