Polycystic ovarian syndrome is metabolic and reproductive disorder which is growing especially in Asian countries. Compounds from Camellia sinensis (L.) leaves can be used against PCOS with improved hepatic, renal and pancreatic profile. In current study, Letrozole (1.0 mg/kgb.w./day) induced adult healthy female Sprague Dawley rats (150-200gm) had been treated with metformin (50 mg/kg b.w.) and polarity based C.sinensis (L.) leaves extracts (50 mg/kg b. w.) for followed by hormonal and metabolite profiling by standard kit method and histological analysis of ovary, uterus, hepatic, renal and pancreatic tissues at 40X.Statistically analyzed results (p<0.0001) showed that LH, testosterone, HOMA-IR, ALT,AST,ALP and bilirubin in PCOS model decreased in rats treated with dist. water extract (1.2± 0.4 mlU/ml, 1.2±0.4 ng/dl, 0.054 ±0.03,50.0±4.35 IU/L,208.3 ±17.4 IU/L,192.6±17.4 IU/L,0.1 ±1.6 mg/dl) as compared to metformin (0.9± 0.4 mlU/ml, 2.09±0.078 ng/dl, 0.24 ±0.03, 33.3.6 ±14.0 IU/L,181.3 ±32.0 IU/L,115.3 ± 30.8 IU/L,0.8±0.1 mg/dl) respectively. Increase in FSH and progesterone level in animals treated with n-hexane extract was statistically significant (6.03±0.32 mlU/ml and 9.72±2.3 pg/dl) as compared to positive control group (2.13±0.99 mlU/ml and 9.05±1.27 pg/dl) respectively while this extract reduced estradiol level significantly in rats treated with n-hexane extract and metformin (48± 5.2pg/ml). Concentration of urea creatinine and uric acid has been decreased significantly by ethyl acetate extract (36.6 ±10.1mg/dl,0.56±0.05mg/dl,3.9±0.04mg/dl) as compared to metformin(37.33 ±4.04 mg/dl,0.63 ±0 mg/dl,3.4±1.04) respectively. Histopathological observation endorsed that PCOS induced rats showed typical peal string cystic follicle like appearance and ovarian parenchyma under ovarian stoma with mild inflammation of liver and interstitial nephritis in kidney, while pancreatic tissues were normal and this restoration was more evident in rats treated with dist. water extract. Active compound behind this study can be a useful tool for pharmaceutical companies.