A rapid, accurate, and precise chromatographic method was developed. The instrument used was Shimadzu LC-10ATVP UV/VIS detector SPD-10AVP. The stationary phase used was Phenomonex ODS C18 reverse-phase (250 x 4.6mm), 5µm particle size. The method was optimized with Acetonitrile: buffer (80:20v/v) as mobile phase and detection wavelength as 254nm. The retention time for sitagliptin was found to be 2.4 and for simvastatin 7.8. The diluents used were distilled water and mobile phase. The correlation coefficient was found to be 0.999 i.e., within the specified range (NLT0.996). All the parameters such LOD (0.00098µg/ml), LOQ (0.0028µg/ml) for Sitagliptin and for simvastatin LOD (0.00016µg/ml), LOQ (0.0005µg/ml) standard deviation (1.361) for Sitagliptin and (0.7211), were found to below. The percentage recovery results were found to be within the specified range (97-103%). The method was successfully applied for the simultaneous determination of sitagliptin phosphate and. simvastatin from the combined dosage form.