Manuscript Title:

IMPACT OF QUERCETIN/ZINC COMPLEX ON WOUND HEALING EFFICIENCY AND ANTI-OXIDANT STATUS IN ZEBRAFISH DANIO RERIO

Author:

SHALINI ELUMALAI, SANGEETHA SOUNDARARAJAN, PETCHIAMMAL KANAGARAJ, DEEPA RANI SADHASIVAM

DOI Number:

DOI:10.17605/OSF.IO/CGZPX

Published : 2022-04-23

About the author(s)

1. SHALINI ELUMALAI - PG & Research Department of Zoology, Pachaiyappa’s College, Chennai, Tamil Nadu, India.
2. SANGEETHA SOUNDARARAJAN - PG & Research Department of Zoology, Pachaiyappa’s College, Chennai, Tamil Nadu, India.
3. PETCHIAMMAL KANAGARAJ - PG & Research Department of Zoology, Pachaiyappa’s College, Chennai, Tamil Nadu, India.
4. DEEPA RANI SADHASIVAM - Assistant Professor, PG & Research Department of Zoology, Ethiraj College for Women, Chennai, Tamil Nadu, India.

Full Text : PDF

Abstract

Quercetin is widely spread in plant life and herbal ingredients and has been linked to a variety of positive activities such as antioxidant and wound healing properties. Additionally, Zn plays a critical role in several biological functions. In the present study, Quercetin derived from Indigofera aspalathoides was complexed with Zn and its antioxidant and wound healing properties were assessed using the zebrafish model. In the initial assessment, LDH, Catalase, GST and GSH activities were assessed in zebrafish upon exposure to different concentrations of Qn/Zn complex. LDH, Catalase, GST and GSH activities were dose-dependently increased and the blood cell count also increased in the haematological analysis. Finally, a skin wound was made in zebrafish and different concentrations of Qn/Zn complex were exposed and wound healing activity was measured. As expected this complex potentially increased wound healing properties by the enhanced antioxidant potency. Overall, the study emphasised that Qn/Zn promotes wound healing by increasing antioxidant properties.


Keywords

Quercetin; Zinc; Zebrafish; Wound healing; Anti-Oxidant