Sepsis is a significant illness that affects millions of individuals throughout the globe each year. 1 In the United States (US), sepsis affects around 750,000 people a year and kills 215,000 people. The annual economic cost of this illness to the US reached 16.7 billion dollars. Sepsis affects practically all organs and systems. A negative impact is also felt on the hemostatic system. 40% of patients suffering from severe sepsis had platelet counts under 80,000/mm3, on average. The severity of the illness is correlated with decreased platelet counts. The average size of the platelets in the blood is determined by the term "mean platelet volume" (MPV). In destructive thrombocytopenia, MPV levels are high, whereas in hypoproliferative thrombocytopenia, MPV levels are low. Platelet size variation is shown by the platelet distribution width (PDW). PDW readings typically range from 10% to 17.9%. MPV and PDW are often used in health care settings all around the globe. Sepsis has been associated with higher MPV and higher PDW levels. The impact of these variables in severe sepsis, however, has not been studied. The purpose of our investigation was to determine if there was any connection between platelet indices (PDW, and MPV) and severe sepsis.