Background Spinal cord injury (SCI) is the damage to the spinal cord that results in loss of function such as mobility or feeling. Aim of the study: evaluate the effect of educational program on nurses’ performance for patients with spinal cord injury. Design: A quasi-experimental design was utilized to achieve the aim of the current study. Setting of the study was carried out in General intensive care unit at El demrdash Hospital. The sample of the study. A convenient sample of 35 nurses. Tools for Data collection. Tool (I) Selfadministered Questionnaire: First part: it is concerned with the characteristics of nurses under study such as age, gender, educational level, and years of experience. Second part: it is concerned with the assessment of nurses' level of knowledge regarding to care of patient with spinal cord injury. Tool (II) Nurses’ practice observational Checklist. It is concerned with the assessment of the nurses’ practice regarding care of patient with spinal cord injury. Tool (Ⅲ) Nurse’s attitude Likert scale toward care of patient with spinal cord injury: It is concerned with assessment of the nurse’s attitude toward caring of patient with spinal cord injury. Results: it revealed that 28.6% the studied nurses had total satisfactory knowledge level regarding spinal cord injury care at pre-program phase compared to 85.7% at post-program phase, and 68.6% at the follow up phase with high statistically significant difference between pre/post phases, and pre/follow-up phases. While, the total satisfactory level of practice of the studied nurses regarding care of patient with spinal cord injury was 17.10 % at the pre-program assessment compared to 74.30% at postprogram assessment, and 60 % at the follow up with high statistically significant difference between pre/post (x2=23.026, P<0.001), and pre/follow phases (x2=13.566, P<0.001). Conclusion: educational program had positive effect on the performance of the studied nurses caring of patient with spinal cord injury with statistically significance improvement in the total satisfactory level of knowledge, attitude and practice throughout program phases. Recommendations: it should develop a system to evaluate nurses’ performance periodically to determine strategies for upgrading and enhancing their performance continuously with strict follow up plan during patient care.