Atraumatic care refers to all therapeutic interventions administered by the nurses caring for children that will reduce the psychological and physical distress suffered by children and their families. Aim of the study: To evaluate the effect of atraumatic care program on nurses’ performance for children undergoing cardiac surgeries. Design: A quasi-experimental design was used to conduct this study. Sample: A convenient sample of all staff nurses in cardiac intensive care unit. A convenient sample of children with heart diseases undergoing cardiac surgeries cared by nurses in the time of atraumatic care program conduction. Setting: The current study was conducted in two cardiothoracic intensive care units at Cairo University Specialized Pediatric Hospital. Tools for data collection: Tool I, structured interview questionnaire and Nurses’ Knowledge Assessment Sheet regarding Atraumatic Care. Tool II An observational checklist: Tool III Nurses’ Attitude Assessment Sheet about atraumatic care: Tool IV: Child’s Assessment Sheet: Results There were direct positive correlation between knowledge, attitude and skills of the studied nurses after atraumatic care program implementation. Conclusion: The current study concluded that there were statistical significant differences in the level of knowledge, skills, and attitude among the studied nurses in pre and post program conduction. Half of the children who received care by the studied nurses had hiegher comfort level. Recommendation: it was recommended that Integrate the atraumatic care program for nurses while caring the children.