This report describes how the coordination of FeCl2 with tris(pyridin-2-ylmethyl)amine (TPA) ligands offers the possibility to activate molecular dioxygen in biomimetic processes. . It includes all processes that are used for larger oxidation reactions that are carried out in nature under certain conditions. The aim of this article is to present the result of a thorough study for complex coordinations involving ligands substituted by groups known as electron donors. It demonstrates how ligands with methoxy substituents are likely to be demethylated, and therefore provides moieties that are potentially synthetically useful. Aiming to modulate the electronic properties at the metal center, a new type of ligand (MeO)2TPA was prepared and the complex of (MeO)2TPAFeCl2 was probed by UV-visible light; 1H RMN paramagnatic and conductometry. The effect of the m -substituted (MeO) group on the structure as well as the effect of the substitution on the oxygenation of the complex was verified. Subsequently, the reactivity of the complex towards molecular oxygen in the absence of substrate is checked by UV-visible, 1H-RMN paramagnetic and radiocrystallography. In addition, reactivity in the presence of substrate is tested.