Acetaminophen-induced toxicity in mice was tested for hepatoprotective activity of ethanolic extracts of Elettaria cardamomum and Trachyspermum ammi. Forty-two (42) male BALB/c mice (n = 42) were divided into nine groups (n = 7). First Group (control group), second group Acetaminophen (500 mg/kg i.p.), third group Acetaminophen + ethanolic extract Elettaria cardamomum P/O at100mg/kg, fourth group, Acetaminophen+ ethanolic extract of Trachyspermum ammi P/O at a dose of 100mg /kg, fifth group, Acetaminophen + ethanolic extract of Elettaria cardamomum and Trachyspermum ammi in a combined ratio of 1:1, P/O at a dosage of 100mg/kg, sixth group was given Acetaminophen + silymarin 200mg/kg. On the 7th day, blood was collected by cardiac puncture technique to estimate serum direct and total bilirubin. The liver was harvested for histopathological Examination. The ethanolic extracts of Elettaria cardamomum and Trachyspermum Ammi at 100mg/kg, p.o. (1:1) significantly improved bilirubin levels. Histopathological studies were significantly improved. We concluded that Elettaria cardamomum and Trachyspermum Ammipossess hepatoprotective, anti-inflammatory, and antioxidant properties.