This study examines the relationship between social networking and the economic sustainability of printing businesses in South-East Nigeria. Despite the growing body of research on the influence of social networking on business sustainability, there is a significant gap in the literature regarding the specific implications for printing businesses in the South-East region of Nigeria. While studies have explored the influence of social networking on economic sustainability in various industries, there is a lack of research that specifically addresses the printing industry in this specific geographical context. Hence, this study fills this gap by examining the relationship between social networking and economic sustainability with focus on printing firms in South-East, Nigeria. The study employed a quantitative research design, which involved the collection and analysis of data through structured questionnaire distributed to printing business owners and managers in South-East Nigeria. The study adopted purposive and snowball sampling techniques of 15 printing businesses in the region, which were selected based on their size, location, and years of operation. Copies of the questionnaire were distributed face-to-face, email, WhatsApp and Google Form. Responses were received from a total of 213 respondents comprising owners, managers, supervisors, social media handlers, IT personnel and support staff from the 15 printing businesses. The research hypotheses were tested using the Kendall’s tau correlation coefficient. The correlation coefficient of 0.3 and above at a 5% level of significant was considered significant and acceptable. The findings reveal that social networking plays a significant role in the economic sustainability of printing businesses in South-East Nigeria. The study also highlights the specific social networking platforms that are most effective in promoting businesses and engaging with customers. The results have implications for policymakers, printing business owners, and marketing professionals, who can leverage social networking to promote economic sustainability in the region's printing industry. In addition, the study contributes to the literature on the intersection of social networking and economic sustainability and provides practical insights for businesses in emerging markets.