Background: This study aims to determine the effect of administration of red ginger (Zingiber officinale var. Rubrum) rhizome extract cream on changes in acute inflammation in test animals white rats (Rattus norvegicus) Wistar strain.

Material and methods:This type of research is a laboratory experiment that aims to see the antiinflammatory effect of using red ginger (Zingiber officinale var. Rubrum) rhizome extract cream on white rats (Rattus norvegicus) wistar strain. The preparation of red ginger (Zingiber officinale var. Rubrum) rhizome extract cream with all concentrations of 1%, 3% and 5% gave an acute inflammatory healing effect because the active substance contained in the red ginger rhizome (Zingiber officinale var. Rubrum) was gingerol.

Result: Where gingerol has an anti-inflammatory effect due to its strong inhibition of prostaglandin biosynthesis. Based on the research results that have been obtained, it can be concluded that the red ginger rhizome extract (Zingiber officinale var. Rubrum) can be formulated in cream preparations.

Conclusion: The formulation of the red ginger (Zingiber officinale var. Rubrum) rhizome extract cream had an anti-inflammatory effect in research animals of white rats (Rattus norvegicus) Wistar strain. Based on statistical tests using One Way ANOVA, it was shown that the most effective formulation for providing antiinflammatory effects was F2 (preparation of red ginger (Zingiber officinale var. Rubrum) rhizome extract cream) 3%).