Background: Burns are one of the most devastating injuries worldwide, burn injuries are a type of skin and tissue damage. Moreover, wound care of burned skin are frequently caring procedure but it is usually accompanied by pain. Virtual reality (VR) technology has been widely used in recent years, as an effective and safe strategy for management of pain associated with burn wound care. Head mounted displays (HMD) has made VR now more feasible for clinical use. Aim of the study: The aim is to evaluate the effect of virtual reality technology on wound care pain among patients with burn. Design: One-group pretest-posttest quasi-experimental design was used in the study. Setting: The study was conducted in two settings, the first was the burn units affiliated to Cairo university hospitals, while the other was the burn unit affiliated to a governmental hospital affiliated to Ministry of health, Egypt. Sample: A convenient sample of 60 male and female adult conscious patients with burn who fulfilled the eligibility criteria was recruited. Tools: Two tools were utilized to collect data; Demographic and Medical Data Questionnaire (DMDQ), Short-Form McGill Pain Questionnaire (SF-MPQ). Results: The mean age of the study sample was 35.40 ± 14.603 years and 43.3% of study sample their age ranged between 18 < 31 years; the female gender represented about 53.3 %. Concerning pain scores; there are high statistical significant differences between Visual Analog Scale (VAS) in the 2nd wound care without using VR and 3rd and 4th wound care with VR, where T= 18.271 P=.000, T= 23.516 P=.000 respectively. Conclusion: The application of VR technology during burns wound care decrease pain severity of burn wound care. Recommendation: Application of VR technology during burn wound care is an effective non-pharmacological pain management strategy/technique.