Polyhedral formulations have been used globally with as per documented records especially in Greek, ancient Chinese, Indian and Egyptian systems of medicines for diverse therapeutic purposes. According to World Health Organization: 80% of the world’s population use traditional medications. In Ayurveda, Siddha and Unani system of medicines, single or multiple herbs (polyherbal) crude drugs belonging to any of 5 sources of medicines i.e., plants, animal, metals and minerals, marine and microorganism are used for the treatment. Use of only bioactive compounds of plants is not sufficient to attain desired therapeutic effects. Combinations of multiple herbs in a specific ratio often provides better therapeutic efficacy with reduced toxicity. This review mainly focuses on importance and clinical significance of Safoof-e-Sharma. The Safoofe-Sharma (Muayyan-e-Hamall) is a polyherbal formulation that was formulated by Hakeem Hans Raj Sharma to treat the women suffering from Leukoria, Gonorrhea, recurrent miscarriage, menstrual disturbances, premature birth and infertility. The regional practices declare that if the drug is used immediately after the completion of menstual cycle, for 7 days the female would definitely conceive within one or otherwise three months. Also, the fetus will always be a male baby or with XY gene combination. It is consisted of 4 crude drugs named as aerial roots of Ficus religiosa,seeds of Skimmia laureola and Mesuea ferra and tusks of Elephas maximus.