Snakehead fishes are a member of Channidae family. Channa striata is one of the most important fish belonging to Channidae family. C. striatais a commercially important fish and it has a high market price in the fish market in Pakistan. The fish are sometimes affected by parasites which cause severe damage to fish growth and significant economic loss in its production. Pollution is the main factor for the spread of such parasites and the experimental fish became their host. In order to check the ectoparasitic prevalence in male and female populations of Channa striatafrom Keenjhar Lake, district Thatta. The study suggested the highest prevalence during summer, in the month of June was 21.66 and the lowest prevalence was3.33recorded in January. Among the infected fish, the number of female fish was higher than that of male fish. Two ectoparasites were found Argulus sp. and Lernea sp. The most infected parts of fish were the scales, fins, and gills where most of the parasite population was seen.