This study aims to examine the effect of leader member exchange, adaptability culture, and psychological capital on Individuals Readiness to Change with change fatigue as a moderator. Empirical data were collected from 723 permanent employees of BPJS Health using an online survey method. This study was analyzed using the SPSS application program with multiple regression analysis to test the seven hypotheses proposed. The results show that adaptability culture and psychological capital have a positive and significant effect on Individuals Readiness to Change with change fatigue not as a moderating variable of the relationship between leader member exchange, adaptability culture, and psychological capital on Individuals Readiness to Change. This research is expected to contribute to policy makers in the field of human resources to identify individual readiness to change as well as to anticipate change fatigue that occurs especially in the public sector.