Reporting errors is fundamental to error prevention. Therefore, the HCWs' response to accidents and injuries is one of the most crucial aspects of the incident reporting system (IRS). Our study aims to synthesize the literature on HCWs' perceptions of the IRS to influence health policy regarding building a culture of safety in healthcare organizations. Methods: Following the PRISMA statement, we searched CINAHIL, PubMed, and Scopus databases to perform a systematic review. Reviews on hospital settings, published from January 2017–January 2022, were considered. The quality of the studies selected was assessed using the qualitative quality assessment instrument. This tool was taken directly [15.]Results: Ten studies met the selection criteria and were included in the study. Positive perceptions of the importance of IRS to patient safety were reported, but these perceptions varied by specialty, hospital, and between senior and healthcare workers. Stress, anxiety, individual work, documentation, devices and equipment, resource constraints, employee turnover, dynamic imbalance, the burden of working conditions, lack of responsibility, psychological safety, and the behavior of workers in closed units are all risk factors that compromise patient safety and IRS. Conclusion&recommendation: To improve patient safety and IRS learning, hospital and health care administrators should implement no punitive reporting procedures to increase HCW compliance. Inadequate infrastructure, low-quality materials, outdated equipment without routine maintenance, and increased work load must be addressed to increase IRS compliance.