Aim: This study aims to compare the effectiveness and outcomes of various subtypes of PRF such as Advanced PRF (A-PRF), Injectable PRF (I-PRF), and Standard PRF (S-PRF) in the healing process following third molar surgery. Materials and Methods: Seventy five patients in the age group between 18 and 35 years old with bilaterally impacted mandibular third molar teeth which requires surgical removal were included in this study. Right side was taken as the study group for placing A-PRF, I-PRF and S-PRF. The left side was taken as the control group. A-PRF was placed for 25 patients (7 males, 18 females; Tooth number-48), I-PRF was placed for 25 patients (9 males, 16 females; Tooth number-48) and S-PRF was placed for 25 patients (6 males, 19 females; Tooth number-48). On the first and third days, postoperatively, the swelling was calculated by measuring the distance between several facial landmarks, the pain was evaluated with the use of a visual analog scale (VAS), and mouth opening was assessed by measuring inter-incisal and soft tissue healing by Turnbell et al method. Results: The mean pain score was higher on the first day for A- PRF over I-PRF and S-PRF, while after 1 week the pain score lowered for APRF over I-PRF and S-PRF. The swelling was more in I-PRF over A-PRF and S-PRF, while after 1 week the swelling regressed for A-PRF over I-PRF and S-PRF. The mouth opening was more in I-PRF over APRF and S-PRF, while after 1 week the mouth opening improved for A-PRF over I-PRF and S-PRF. Conclusion: From this study, we conclude that the platelet rich fibrin showed better effects on healing process after third molar surgery. Out of which, Advanced PRF group showed decreased pain and swelling, increased mouth opening, and improved soft tissue healing as compared to other subtypes used in this study.