Aim: To determine the prevalence of Hepatorenal syndrome in liver cirrhosis patients due to chronic hepatitis B and C. Study design: A cross-sectional study. Place and Duration: Bilawal medical college hospital Kotri between the duration of December 2019 to December 2020. Methodology: Overall 100 patients with liver cirrhosis (with complete history, examination and investigations like HBSA, Anti HCV) irrespective of sex and race were included in this study. Liver cirrhosis was diagnosed by clinical and laboratory criteria which include: decreased liver span, splenomegaly, ascites, raised prothrombin time, low serum albumin, low ascitic fluid albumin, SAAG ratio of more than1:1. The patients who have creatinine 2mg/dl or more were further analysed for Hepatorenal syndrome. Results: This study showed that renal dysfunction was very common among patients with cirrhosis and ascites. Hepatorenal syndrome was the major cause of kidney dysfunction. Other causes of renal impairment included spontaneous bacterial peritonitis (SBP) primary renal disease with a history of prolonged analgesia and hypovolemia. Out of 100 patients, only 33 of patients had altered renal function. Out of 33 patients, only 2 patients had got normal serum creatinine after getting normal saline infusion after withdrawal of diuretics. Nine patients had decreased serum creatinine below 1.5mg/dl after receiving appropriate antibiotics for infection. Eight patients had primary renal disease as indicated by altered urine D/R and/or U/S of kidneys. Two patients had a history of taking prolonged NSAIDS or nephrotoxic drugs. Overall only Twelve patients had Hepatorenal syndrome (HRS). Conclusion: Hepatorenal syndrome should only be identified when all other potential causes of renal impairment have been ruled out. It is an illness of exclusion. Patients with cirrhosis and ascites frequently have a medical complication known as Hepatorenal syndrome (HRS). Based on the data gathered for this investigation, HRS was found to be the most frequent cause of renal impairment in these patients, followed by hypovolemia, primary renal disease, analgesic nephropathy, spontaneous bacterial peritonitis, and other reasons.