Hepato-renal toxicity is a common complication of diabetic hyperlipidemia due to disease and its therapeutic drugs. Increased intake of tea (Camellia sinensis L.) is associated with a lower risk of hyperlipidemia and its related disorders. Aim of current study was to evaluate hepato-renal therapeutic effects of intraperitoneally induced 25mg/ml/kg b.w. of n-Hexane, ethyl acetate, methanolic and water extracts of partially processed C. sinensis(L.)leaves against streptozotocin-induced(55mg/ml/kg b.w.) diabetic hyperlipidemia in albino Wistar rats (both genders, 300- 400 g), by keeping metformin (250 mg/ml/kg b.w.) as positive control and high fed diet as negative control, followed by the estimation of biochemical, hormonal (by kit method) and histological profile of blood, hepatic and renal tissues of animals. Statistically analyzed results (at p≤ 0.05) showed that C.sinensis(L.) extracts significantly improved ALT (52.2±4.8 U/L), AST (57.14U/L), ALP (148±25U/L),bilirubin (0.13±0.02 mg/dl), albumin (2.4±0/dl), globulin (1.8±04mg/dl), A/G ratio (0.8±0.6mg/dl), proteins (4.9±0mg/dl), urea (41.1±1.8mg/dl), creatinine (1.0±0.1mg/dl) and uric acid (2.16±16mg/dl), as compared to negative control group[ALT (85±5.8U/L), AST (162.1±10.1U/L), ALP (150.3±41U/L), urea (66mg/dl), creatinine (1.2±0.2mg/dl) and uric acid(5.1±4mg/dl)].Effects of plant extracts were almost similar to positive control group as their ALT (81 U/L), AST (183±3U/L), ALP (338U/L), urea (56.2±25mg/dl), creatinine (0.81mg/dl) and uric acid (4.42±9mg/dl) were nearly equal. Histopathological analysis showed recovery of the glomerular structure of the renal and hepatic tissues, along with a reduction in mononuclear cell infiltrate and improvement in steatosis changes. Current results can be used for the isolation of active compounds behind the study through in silico, in vivo and in vitro approaches.