Chalcones have a simple privileged scaffold and are active lead molecules in medicinal chemistry for the discovery of new drugs. Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,βunsaturated ketone. Chalcones and their derivatives have a huge importance in medicinal chemistry, displaying a wide range of pharmacological activities including analgesic activites. A variety of important biological compounds are known collectively as chalcones or chalconoids. In this view medicinal chemists are also trying to speed up drug discovery process for finding the lead molecule (Thomas et al. 1998). The compounds with chalcone as backbone have been reported to possess varied biological and pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, cytotoxic, antitumor, antimalarial, antitubercular, antiviral, anti-HIV, antiulcerative, antileishmanial activities.All the newly synthesized pyrimidines were characterized by means of IR, ¹H- and ¹³C-NMR, Electron Ionization (EI)- mass and elemental analyses and screened for analgesic activities. Pyrimidines also displayed better analgesic activity.