Aim: The study aims to evaluate the effectiveness of nursing intervention on knowledge and practice towards care of children undergoing liver surgeries. Research design: A quasi-experimental design was used. Setting: The study was conducted at Pediatric Surgery Unit in the Children’s Hospital that affiliated to Ain shams university hospitals and Liver Surgeries Unit that affiliated to Air Force Specialized Hospital / Cairo/ Egypt.

Sample: A purposive sample of 50 nurses, from the previously mentioned setting during the period of six months. Tools: two tools were used to collect data namely: A structured interviewing questionnaire and standardized observational checklists (pre & post) to assess nurses’ knowledge and practice regarding care of children undergoing liver surgeries.

Results: There was highly statistically significant improvement in posttest compared to the pretest results regarding the nurses’ knowledge and practice about care of children undergoing liver surgeries where P<0.001.

Conclusion: Nursing intervention was effective in improving nurses’ knowledge and practice regarding care of children undergoing liver surgeries. Recommendations: Adopt nursing intervention based on actual need assessment of nurses regarding care of children undergoing liver surgeries.