Background: Medical Devices Related Pressure Ulcer are skin breakdown due to certain medical devices. Aim: Assess nurses’ level of knowledge and practice regarding medical devices induced ulcer among critically ill patients. Design: Descriptive exploratory research design. Setting: General Intensive Care Unit of Beni-Suef University Hospital. Subjects: All nurses (40 nurses) from General Intensive Care Unit of Beni-Suef University Hospital. A convenient sample of all available nurses who worked at the previous mentioned setting. Tools: The investigator prepared an interview form including two tools. Tool (I) Selfadministered Interview Questionnaire consisted of 2 parts; Part (I): Questionnaire to assess demographic characteristics of studied nurses. Part (II): Questionnaire to asses’ nurses’ level of knowledge regarding medical devices induced ulcer. Tool (II) Observational checklist to assess nursing care of endo tracheal and tracheostomy tube. The main results of the present study: the study results revealed that more than three fifth of the studied nurses were having unsatisfactory total level of knowledge and less than three fifth of the studied nurses were having incompetence total level of practice regarding medical devices induced ulcer among critically ill patients. Conclusion: It can be concluded that there was statistically significant positive correlation between nurses’ total level of knowledge and their total level of practice. Recommendation: Develop and implement intervention program to improve nurses’ performance regarding medical devices induced ulcer among critically ill patients.