Background: Nursing Crew Resource Management (NCRM) training program is a modified version of Crew Resource Management (CRM) training program and its concept of managing errors associated with the effects of human factors on skills. NCRM is a training program designed to improve nurses’ knowledge, performance, and confidence related to patient safety in health care.

Aim: This study aims at investigating the effect of nursing crew resource management (NCRM) training program on nurse interns' confidence related to patient safety.

Research design: Quasi-experimental one group pre and post-test design was used to carry out this study. Study setting: The study was conducted at Ain-Shams University Hospitals. Study subjects: 139 nurse interns whom are succeeded in fourth year at faculty of nursing Ain-Shams University.

Tools: Data were collected by using Patient Safety Knowledge Questionnaire, Observational Checklist for Nurse Interns’ Safety Performance and Health Professional Education in Patient Safety Survey (H-PEPSS).

Result: Demonstrate that 6.5 % of the nurse interns had satisfactory knowledge, 0.00% had adequate performance, and 25.2% had high confidence at the pre-intervention phase. This rose to74.8 % of the nurse interns had satisfactory knowledge,97.8% had adequate performance, and 86.3 % had high confidence at the post- intervention phase, and declined to 37.4 % of the nurse interns had satisfactory knowledge,43.5% had adequate performance, and 73.4 % had high confidence at the follow up phase. The differences were statistically significant (P <0.001).

Conclusion: NCRM training program produced significant improvement in the nurse interns' knowledge, performance, and confidence related to patient safety. Recommendations: Implementing NCRM training program is highly recommended for nurses to improve knowledge, performance, and confidence related to patient safety.