objective: This study aimed to evaluate and compare pre- and post-operative corneal changes in eyes treated with silicone oil tamponade. Methodology: A comparative cross-sectional study was conducted at Al-Shifa Trust Eye Hospital in Rawalpindi, Punjab, Pakistan, enrolling subjects using a non-probability
consecutive sampling technique undergoing silicone oil tamponade. Detailed ocular examination of the anterior and posterior segments was performed with slit lamp biomicroscopy. Corneal parameters, including principal corneal curvature K1, K2, its average KAVG, central corneal thickness (CCT), and anterior chamber depth (ACD), were measured with IOL Master 700 pre- and post-operatively. Data were entered and analyzed using DATATAB online web-based software. Results: A total of 50 subjects participated, including 34 (68%) males and 16 (32%) females, with a mean age of 48.10 ± 18.55, ranging from 10 to 80 years. The mean pre- and post-operative values for K1, K2, KAVG, CCT, and ACD were 42.93 ± 1.91, 44.67 ± 1.80, 43.87 ± 1.63, 529.14 ± 37.02, and 3.79 ± 1.02, and 42.71 ± 1.82, 44.74 ± 2.01, 43.81 ± 1.77, 531.74 ± 38.18, and 3.99 ± 1.00, respectively. Comparing pre- and post-operative corneal parameters after one-month follow-up, no significant changes were observed. However, a statistically significant increase in ACD was observed (p < 0.002). Conclusion: No significant changes in corneal parameters occurred in eyes with silicone oil tamponade, while an increase in anterior chamber depth was observed.