World Health Organization (WHO), in 2020, ovarian cancer ranks as the fourth most common cancer found in women in the world after breast cancer, colorectal cancer, and uterine corpus cancer. More than 200,000 deaths are recorded annually, which are predominantly women with weak economies in both developing and developed countries. The country with the highest number is sub-Saharan Africa, including South Africa (40/100,000). In Africa. Ranks sixth in Indonesia as a cancer disease. This type of research is a case control study with a retrospective approach (retrospective study), namely research that explains the relationship between the effect (ovarian cancer) and internal risks (family history, parity), and external risks (use of oral contraceptives, Drugs that increase fertility) The results of the study illustrate that there is a relationship between family history and the incidence of ovarian cancer at Melati Perbaungan General Hospital Medan.Based on the results of the study it was found that the variables associated with the incidence of ovarian cancer in the Pirngadi Medan General Hospital, family history, were p=0.000 (p<0.05) with OR=12.00, parity p=0.001 (p<0, 05) with OR=9.07, contraceptive use p=0.001 (p<0.05) with OR=11.08 and use of fertility drugs p=0.027 (p<0.05) with OR=4.50). It is suggested to health workers that promotion efforts be made to the public regarding factors related to the incidence of ovarian cancer but primary prevention efforts also need to be carried out. And to mothers who have paid attention to and care about the factors that influence the incidence of ovarian cancer and good health practices are expected to continue to maintain them.