Background: Laparoscopic cholecystectomy is the "gold standard" surgical treatment of symptomatic gall bladder diseases. The study aimed to evaluate the effect of pre-operative education on post-operative outcomes of laparoscopic cholecystectomy patients. Methods: Quasi-experimental design including a purposive sample of 100 adult patients. Results: 13% of patients had a satisfactory level of pre-operative knowledge which improved to 93% after education. Furthermore, 5% of patients had a satisfactory level of practice which improved to 90% after education. Conclusion: Education has a significant positive impact on patients’ knowledge and skills. Recommendation: Continuous patient education through audio-visual materials, courses and follow-up of patient outcomes. Highlights: 1. Before health education, the level of patients’ knowledge is unsatisfactory. 2. Preoperative health education has a positive effect on patients undergoing laparoscopic cholecystectomy. 3. Patient knowledge and practice was significantly improved after the education. 4. Continuous patient education through audio-visual materials and regular follow-up sessions are important for improving patients' information and skills.