Background: The current preferred method for treating open fractures is the use of external fixator systems, which are considered the most effective due to their ability to provide adequate soft tissue coverage and ensure stable internal fixation. Aim: The study aimed to assess self-care management among patients with external fixators. Design: This study employed a descriptive research methodology. Setting: This study was done in orthopedic departments and orthopedic outpatient clinics at Main Mansoura University Hospital and Emergency Hospital. Sampling: A sample of 66 patients with an external fixator was selected purposefully. Tools: Two tools were utilized in this study to collect pertinent data. Tool I was the structure interview questionnaire sheet, and Tool II was the patient's self-care practice checklist (reported practice). Results: A total of 84.8% of the participants’ knowledge regarding the first knowledge domain (patients’ knowledge about an external fixator) was unsatisfactory. Moreover, 97% of the participants had an unsatisfactory knowledge level about the second knowledge domain (patients’ information about self-care activities). About 57.6% of the participants had an unsatisfactory practices regarding wound-pin site care. Furthermore, 87.9% and 93.9% of the studied patients had unsatisfactory practice concerning neurovascular assessment and the performance of isometric exercises, respectively. Conclusion: The entire group had unsatisfactory knowledge level about self-care activities for external fixation. In addition, the entire group had unsatisfactory practices about self-care activities for external fixation. Recommendations: It is imperative for educational and training programs to be meticulously designed in order to assist patients undergoing external fixation in acquiring and enhancing their understanding and implementation of self-care strategies regarding external fixations