Psoriasis is an autoimmune disorder which can pose a major public health problem and contribute to rising health care expenses, lowering people’s quality of life and capacity to work. Patient education seems to be essential for improving psoriatic patients outcomes, such as self-care practice skills, medication adherence, and consequently their overall quality of life. Aim: To evaluate the effect of educational intervention on outcomes of patients with psoriasis. Design: A quasi-experimental research design was utilized. Setting: This study was conducted at the Dermatology, Venereology, and Andrology department and outpatient clinics at Mansoura University Hospital. Subject: A purposive sample of 70 adult patients diagnosed with psoriasis was selected and divided randomly into two equal groups. Tools: Three tools were utilized in this study; Tool (I): A structured interview questionnaire that consisted of three parts; Part (1): Demographic characteristics, Part (2): Medical data, and Part (3): Patients' reported self-care practices checklist. Tool (II): Modified 12-Item Medication Adherence Scale. Tool (III): Dermatology Life Quality Index (DLQI). Results: The result of this study revealed that after implementation of the educational intervention, there was an improvement in the study group's self-care practices and medication adherence levels, with a statistical significance difference between both groups (p<0.001). Furthermore, the total mean score of DLQI was significantly better in the study group in comparison with the control group. Conclusion: Educational intervention has a positive effect on psoriatic patients self-care practices, medication adherence, and quality of life. Recommendations: Availability of a standardized colored booklet about psoriasis for patients.