The healthcare-associated infections’ Problem is global (IAS), the patients are affected by these infections during their hospitalization in a treatment establishment, because of the population augmentation and the patients’ vulnerability associated to age, to illness and treatment, the increasing rise of the bacterial resistance to antibiotics and the emergence of new microorganisms. These healthcare-associated infections generally and surgical site infections especially, are the most frequent digestive surgical complications. In order to fight the rise of these infections, the prophylactic antibiotic treatment is one of the preventive measures we have to respect. We have achieved a descriptive and a prospective (6) study related to 167 patients who have faced a surgical procedure in digestive cancers at the service of general surgery in the year 2O18. This study analyses the implementation of the prophylactic antibiotic (5) prepared and introduced in our service in the same year. During this study, the prophylactic antibiotic protocol has been respected for more than 90% of our patients in 2018.