Eucalyptus camaldulensis belongs to family myrtaceae and native to Australia, is a tree with such diverse uses that it can be called a multipurpose tree. Eucalyptus is generally used for the reclamation of problematic soils in various parts of subcontinent. The versatile tree is highly vulnerable to several diseases, with the most serious threat being bacterial blight triggered by Xanthomonas axonopodis pv. Eucalypti. Six plant activators i.e. salicylic acid (C7H6O3), benzoic acid (C7H6O2), citric acid (C6H8O7), dipotassium phosphate (K2HPO4), monopotassium phosphate (KH2PO4), 2,4 D Isonicotinic acid and nutritional mixture namely Compound (NPK) and Nutritop (Fe, Zn, Cu, B, Mn) were evaluated in field under RCBD and greenhouse under CRD in the Research area, Department of Forestry and Range Management, University of Agriculture Faisalabad. Out of these six plant defense regulators salicylic acid showed significant results and expressed minimum disease incidence (14.167%), as compared to others under greenhouse and (16.185%) field conditions. In nutritional management, mixture of nutrients viz boron (B), magasium (Mg), zinc (Zn), iron (Fe), calcium (Ca) Nutritop and Compound (NPK) were used alone and in combination. Minimum disease incidence (12.57%) was recorded in greenhouse and field (16.88%) when applied in combination (Compound+Nutriotop) as compared to control. The current relationship concluded that salicylic acid among six plant activators and combination of Compound+Nutriotop is a fruitful tool for the integrated management of the disease.