The contemporary study was designed to find out resistant and potential yield source of available chilli germplasm against bacterial wilt disease and management of bacterial wilt through plant defense activators. The findings of current study revealed that among 25 tested germplasm four cultivars named, Comega CH 403, HHP-090F, HHP-086H and Sanam showed resistant reaction having disease incidence between 1 to 20% respectively, whereas Sitara-80, Maxi and Sitara-83 were found highly susceptible with more than 80% disease incidence percentage. Current study found that, Comega CH 403, Sanam and HHP-086H were the leading varieties in terms of growth and yield contributing attributes, with maximum values of all investigated parameters in healthier conditions, however a small variation among all factors were recorded under disease stress. On the other hand minimum values for all growth parameters and yield were recorded among Maxi, Sitara-80 and Sitara-83 under both, healthy and infected environments with minimum log values. The results from management trials revealed that acibenzolar-S-methyl (ASM) was found highly effective against bacterial wilt with lowest disease incidence (38.63%), followed by chitosan (40.38%), citric acid (41.66%), salicylic acid (42.15%), benzoic acid (43.31%), ASA (45.29%), KH2PO4 (45.40%), K2HPO4 (48.30%), dichloro-isonicotinic acid (50.01%) and hydroquinone (52.43%) under greenhouse conditions. Whereas, treatment of combination of ASM+CS+CA showed least disease incidence (34.16%) followed by ASM+CS, ASM+CA, CS+CA, ASM, CS and CA against bacterial wilt of chilli under natural field conditions. Thus, the Comega CH 403, Sanam and HHP-086H are the potential varieties with high yield and resistance response against bacterial wilt.