Background: Gestational Diabetes Mellitus (GDM) poses significant risks to maternal and neonatal health, particularly in low-resource settings. Patient-centered education has emerged as a critical strategy to empower women with GDM to effectively manage their circumstance. Nevertheless, partial suggestion exists on the effectiveness of organized self-care learning plans in, KPK, Pakistan. Objective: This study aimed to evaluate the effect of an organized self-care education module on glycemic control and maternal neonatal effects among women diagnosed with GDM in a tertiary care setting. Methods: A quasi-experimental pre-test and post-test control group design was employed from November 2024 to March 2025 at a tertiary hospital in Peshawar, Pakistan. A total of 220 pregnant women diagnosed with GDM were enrolled through purposive sampling, with 110 each in the intervention and control groups. The intervention group received a structured, culturally tailored education program based on international DSMES guidelines, delivered over four weeks, while the control group received standard antenatal care. Outcomes, including fasting blood sugar (FBS), random blood sugar (RBS), HbA1c, BMI, and selected maternal and neonatal parameters, were assessed pre- and post-intervention. Results: post-intervention, the intervention group demonstrated statistically significant reductions in FBS (6.24 mg/dL), RBS (10.03 mg/dL), and HbA1c (0.42%) (p < 0.001). Improvements were also noted in BMI and maternal-neonatal outcomes such as reduced rates of cesarean delivery, preeclampsia, and NICU admissions. These results underscore the effectiveness of structured education in enhancing self-care practices and medical consequences in women with GDM. Conclusion: The findings highlight the vital role of culturally contextualized, organized self-care education in refining the management of GDM. Implementation of such interventions at the community and institutional levels could significantly reduce adverse outcomes associated with GDM in resource-constrained settings.