Employee attrition poses significant challenges for comprehensive specialty hospitals, affecting continuity of care, organizational productivity, and patient satisfaction. This research paper aims to analyze the factors influencing employee attrition and retention in comprehensive specialty hospitals through a case study approach. The study will select a representative sample of comprehensive specialty hospitals and collect data through surveys, interviews, and HR records. The surveys will capture employee demographics, job satisfaction, work-life balance, organizational culture, leadership effectiveness, compensation and benefits, and career development opportunities. Qualitative interviews will be conducted with current and former employees to gain insights into their experiences, motivations, and reasons for attrition or retention. HR records will provide information on turnover rates, tenure, and performance evaluations. Data analysis will involve quantitative methods, such as regression analysis and correlation tests, to identify the significant factors associated with employee attrition and retention. The qualitative data will be thematically analyzed to identify common themes and patterns related to attrition and retention factors. The findings will provide a comprehensive understanding of the factors influencing employee attrition and retention in comprehensive specialty hospitals. This knowledge can guide hospital administrators and HR professionals in developing effective strategies to improve employee retention, enhance job satisfaction, and create a positive work environment.