In most economies in Africa, fast-food-restaurants as opposed to traditionally-acceptable food consumption outlets are increasingly gaining prominence and considerable consumers’ footfall. Notwithstanding, concerns are also rising among entrepreneurs regarding unending closures of many fast-food restaurants few years post-commencement. This research investigates the relationships between the Big-FivePersonality traits and consumers repurchase intention in fast food restaurants from the prism of a typical developing economy where fast-food restaurant is still evolving. Additionally, mediating effect of willingness-to-pay and moderating effect of gender were examined. Data from 536 fast-food consumers in 18 fast-food restaurants drawn from three states in the South-South Geo-political Zone in Nigeria were obtained using self-administered questionnaire. Structural Equation Modeling with Analysis of Moment Structures (AMOS) version 22, was used in analyzing data. Findings revealed that openness-to-experience (β = -0.287; t = -3.762; p = < 0.05), and agreeableness ((β = -0.558; t = -3.459; p = < 0.05) have significant negative relationships with re-purchase intentions in fast-food restaurants; conscientiousness (β = 0.527; t = 3.723; p = < 0.05), and extraversion (β = 0.316; t = 3.829; p = < 0.05) have significant positive relationship with re-purchase intention; while neuroticism ((β = 0.058; t = 1.607; p = < 0.05) was not significant in the relationship. Willingness-to-pay was a partial mediator, and gender was a strong moderator in the relationship between the Big Five factors and consumers repurchase intentions in fast food restaurants.