1. AYESHA NAZIR - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
2. IRSHAD AHMAD - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
3. MOHSIN ABBAS KHAN - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
4. ANAM MUBASHIR - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
5. AISHA SETHI - Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad.
6. AKRAM SARWAR - Department of Botany, The Islamia University of Bahawalpur, Pakistan.
Derivatives of tramadol were synthesized by reflux action of tramadol with different amino acids and the structures of new derivatives were confirmed by physical characterization and spectral data; FTIR, NMR analysis. New compounds were screened against anti-inflammatory, analgesic and antioxidant activities. The physical properties like; color, physical state, melting points and the solubility of derivatives in various solvents were determined by respective techniques. All the synthesized products were tested for antiinflammatory activity by carrageenan induced paw-edema in mice and the analgesic activity was evaluated by acetic acid-induced abdominal writhing in mice. The pharmacokinetic profile was predicted using Swiss ADME software. The antioxidant activity of esterified products was tested by DPPH free radical scavenging method. Esterified products of tramadol presented marked analgesic and antioxidant activity. The newly synthesized products also revealed significant anti-inflammatory activity.
Analgesic, Anti-Inflammatory, Derivatization, FTIR, NMR, Physical Data, Tramadol.