Manuscript Title:

SYNTHESIS, SPECTRAL STUDIES, INSILICO STUDIES, BRINE-SHRIMP CYTOTOXICITY, α- AMYLASE INHIBITION AND ANTI-UREASE ACTIVITIES OF MELOXICAM DERIVATIVES

Author:

ANAM MUBASHIR, IRSHAD AHMED, MOHSIN ABBAS KHAN, AYESHA NAZIR

DOI Number:

DOI:10.17605/OSF.IO/7NA8P

Published : 2023-05-10

About the author(s)

1. ANAM MUBASHIR - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
2. IRSHAD AHMED - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
3. MOHSIN ABBAS KHAN - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
4. AYESHA NAZIR - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.

Full Text : PDF

Abstract

The objective of this study was to deal with ester derivatives of meloxicam. In this connection, a series of meloxicam derivatives with carboxylic acids were synthesized and characterized using FTIR, HNMR and 13CNMR. The in-vitro biological activities including brine shrimp cytotoxicity. α amylase inhibition and antiurease activities were evaluated. The most active derived compounds M1, M2, M10 and M15 have shown 60%, 70%, 50% and 50% mortality rate respectively comparable to positive control. All derivatives were found to be non-toxic. Furthermore, the study suggests that synthesized meloxicam derivatives exhibit inhibitory potential against different biologically relevant enzyme targets.


Keywords

α-Amylase, Brine Shrimp Cytotoxicity, C13NMR, FTIR, HNMR, Meloxicam, Urease.