The scientific article presents the results of a study of the incidence of the leading classes of diseases their prediction of the able-bodied population of the Turkestan region (per 100 thousand population). The purpose of the Study. Analysis of morbidity indicators for the main classes of diseases and their prediction in the Turkestan region for the period 2011-2020. Materials and Methods. The paper uses retrospective data for the period 2011-2020 for the Turkestan region. Results. When studying the levels and dynamics of morbidity of neoplasms, diseases of the circulatory system, injuries and poisoning and other effects, diseases of the endocrine system, morbidity of the nervous system, morbidity of the eye and its appendages, morbidity of the ear and mastoid process of the able-bodied population of the Turkestan region (retrospective data for the period 2011-2020) with their forecast for 2021-2023 (per 100 thousand of the total population) is characterized by a weak and medium-pronounced self-oscillatory trend. Conclusion. Thus, drawing conclusions from predictive models based on retrospective data on the incidence of the leading classes of diseases in the working-age population, it can be argued that there is an obvious visible decrease in the predicted levels in the short term. Whether this fact is related to certain reforms in the field of the healthcare system in terms of improving diagnostics, clinical and preventive work will depend on the results of deeper research in the industry.