Background: Ergonomic hazards are a serious health problem affecting nurses and they should give importance to their own well-being. This will, in turn, ensure the best quality of care is delivered to patients. Aim: to assess the incidences of ergonomic hazards among nurses and quality of care at intensive care units in fayoum hospitals Design: Exploratory descriptive design was utilized. Setting: in three general intensive care units with different specialist at three selected hospitals from different organization system as general hospital, insurances hospital, and university hospitals in Fayoum. Those intensive care units were selected according to the type of patient, which is affiliated to ministry of health. Subjects: A convenience sample of all staff' nurses at the selected hospital (n=149). Tools: Three tools were used for data collection; 1) Incidences of ergonomic hazards questionnaire, 2) Factors affecting ergonomic hazards questionnaire and 3) Quality of nursing care observational checklist. Results: There was high incidence of ergonomic hazards (back pain, neck and shoulders pain) among staff nurses working in intensive care unit (88, 2%) at three hospitals. The majority of staff nurses (92%) in insurances hospital, followed by (88.5%) in university hospital, and (83%) in general hospital perceive causes of musculoskeletal disorders in neck and shoulder pain, both university and general hospital). Also showed a statistical significant between the physical layout factors and types of hospitals (C=12.04-0.00). There statistical significant differences(C=2.34, P 0.03) between individual factors and types of hospitals. Also, the highly statistical significant differences negative correlation (r = -0.2, P = 0.88) between the incidences of ergonomic hazards in general hospital and quality of patient care. Conclusion: based on the results of the present study concluded the highly incidences of ergonomic hazards and level quality of patient care in three hospitals was moderate level. In which highly statistical significant negative correlation between the incidences of ergonomic hazards in general hospital and university hospital with quality of patient care. While, there was no statistical significant differences negative correlation between the incidences of ergonomic hazards in health insurances hospital and quality of patient care Also, showed a statistical significant between the physical layout factors and types of hospitals. Recommendations: the study recommended that develop ergonomic safety guideline. Continues quality and skill training for leader and staff nurses, continuous follow up the staffs' performance from nursing leadership to nursing staff.