Background: The COVID-19 epidemic has wreaked havoc around the world, with the Pakistan being hit hardest. A vaccine provides the best hope for a permanent solution to the epidemic. In March 2020, the World Health Organization (WHO) announced that the epidemic COVID-19, first reported in Wuhan, China in December 2019, had become a global epidemic. Expressing "grave concerns" about the spread of the epidemic, the WHO called on governments to take immediate and comprehensive action to stem the tide. Numerous vaccines against coronavirus (COVID-19) have been approved and distributed globally in different regions. However, the general community’s information, attitudes, and perceptions about COVID19 vaccination are not well understood. Thus, the purpose of this study was to investigate community knowledge, attitudes and perceptions about COVID-19 vaccination in Pakistan. Although many vaccines are being developed and in clinical trials, and at least seven vaccines have been distributed worldwide, the desire to adopt the COVID-19 vaccine in a different country, including Pakistan, poses a great challenge to the world. However, no studies have been conducted in Pakistan on the knowledge, attitudes, acceptance and determination of COVID-19 vaccine acceptance. Therefore, the purpose of this study was to investigate the knowledge, attitudes, acceptance and determinants of acceptance of COVID-19 vaccine in the adult population in Pakistan.

Objectives: The main objective of the study was to assess knowledge, attitudes and acceptance of COVID19 vaccination and to improve and enhance the coverage and completion of vaccination.

Methods and materials: This is a cross section web based survey. Registered participants were of Pakistani citizenship and were 18 years of age or older. A questionnaire was created using Google Forms. The link was then distributed through various overall WhatsApp groups in Pakistan. To ensure that participants met the criteria for participation, questions about age, education and nationality were included in the questionnaire.

Results: A total of 200 participants enrolled in this study. Most respondents (44.5%) were between the ages of 18-25 and 42 % were in the 26-35 age group. The majority of them said they would vaccinate as soon as possible (88.02%) and delay vaccination by 12.8%. 93.36% of respondents believe that the vaccine should be available for free and 79% of respondents believe that COVID-19 vaccine development. 82.5% participants are concerned about safety and efficacy.

Conclusions: The most important factor in hesitation of vaccines is the mild or serious side effects after immunizations. Vaccine acceptance may increase when additional information about vaccine safety and efficiency becomes available in the public domain.