Background: Cisplatin chemotherapy is one of the main modalities of therapy that is often given to patients with nasopharyngeal carcinoma which is often combined with Paclitaxel, one of the side effects of Cisplatin can cause damage to the outer hair cells of the cochlea which in turn causes hearing loss caused by the formation of free radicals that cause damage to the outer hair cells of the cochlea. Cochlear outer hair cell death. Ginkgo Biloba is an antioxidant that has an autoprotective effect against the ototoxicity effect of Cisplatin by inhibiting the formation of free radicals.

Objective: To determine the effect of cisplatin and paclitaxel therapy with and without ginkgo Biloba on hearing threshold and function of cochlear outer hair cells in patients with nasopharyngeal carcinoma.

Methods: This study is a double-blind randomized control trial with a pre-post test design, conducted on 18 nasopharyngeal carcinoma patients receiving Cisplatin and Paclitaxel chemotherapy. Subjects were divided into control groups (without giving 80 mg Ginkgo Biloba extract) and treatment groups (who received 80 mg Ginkgo Biloba extract). Pure tone audiometry, tympanometry, and Distortion Product Otoacoustic Emission were examined before chemotherapy, and after the first and second chemotherapy.

Results: There were significant results in the hearing threshold p value = 0.034 (p < 0.05) and DPOAE results with p value = 0.047 (p < 0.05) after the second chemotherapy. There were significant results for the DPOAE examination after the second chemotherapy with p value = 0.010 (p <0.05) in 16 patients (6 treatment patients and 10 control patients) with all type A tympanometry results.

Conclusion: Administration of Ginkgo Biloba 80 mg per day can affect the function of cochlear outer hair cells in nasopharyngeal carcinoma patients with Cisplatin and Paclitaxel therapy.