Introduction: Depression is the most common mental illness and affects more than 10-15% of people. There are a lot of synthetic drugs used to treat depression but these synthetic drugs have potential side effects. Exercise has also been recommended as a complementary therapy that can help improve the symptoms of depressive symptoms and prevent recurrence. Objective: The present study aims to assess the antidepressant effect of Sesbania bispinosa extracts and Physical exercise in rats and in-vivo Biochemical analysis of the rat serum and also antioxidant, antibacterial activity against leaf extract.

Methods: The oral administration of extracts, sucrose consumption test was performed to assess the antidepressant activity. After the end of the experimental treatment period [30 days], the animals were sacrificed serum was collected for the biochemical analysis. Results. The biochemical parameters were carried out as follows. The serum glucose, triglycerides, Total cholesterol, LDL, was found to be increased in group II depressed rats. The HDL, VLDL, amino acids levels were found to be decreased in group II depressed rats. The case was reversed after the treatment with S. bispinosa extract [group IV and V] and in swimming exercise [group VI]. In addition, antioxidant activity results suggested that could be due to polyphenols, but mainly by different molecules or substances present in the extracts and very successful in inhibiting growth of bacterial pathogens. Conclusion: S. bispinosa extract and Swimming exercise has antidepressant activity, antioxidant, antibacterial activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.