In present era, laparoscopic cholecystectomy is the preferred surgery for gall stones. Along with its benefits, it is associated with a significant sympathoadrenal stress response. Various drugs have been used to allay the same. Dexmedetomidine a selective α-2 agonist with sedative, analgesic and sympatholytic properties. The present study was therefore undertaken to evaluate the efficacy of intraoperative administration of 0.4 mcg/kg/hr of Dexmedetomidine infusion in patients undergoing laparoscopic surgeries. The primary objective was to study the impact of Dexmedetomidine in reducing the hemodynamic stress response to laryngoscopy, intubation, pneumoperitoneum, and extubation and secondary objective was to assess the post-operative sedation levels, extubation time and analgesic requirements and adverse effects if any.