Aim: The purpose of this study was to find out the relationship of smoking with demographic and clinical features of Head and Neck Cancer (HNC) patients visiting Nishtar Hospital Multan, Pakistan. Even though there has been a lot of studies conducted regarding the many aspects of HNC around the world, but Southern Punjab, Pakistan, no online information is available to our knowledge. Materials and methods: Demographic and clinical information from HNC patients was obtained and analyzed with respect to smoking. Results: In this study, male patients (65.3%) were more common than female patients (34.7%). Among smoker patients, males were more frequent (88.70%) than females (11.29%). The habit of smoking was identified in 51.2% patients. Among demographic factors, there were statistically significant differences in age, smoking and income (p≤0.05) in both patient groups. Most of smoker patients (88.70%) were from low-income families. In terms of education of patients, a non-significant difference was reported (p=0.987). A significant difference was found according to the all HNSCC subsites (p=0.005). The rate of larynx cancer was more in smoker patients (53%) and hypopharynx cancer was more in non-smoker patients (47%). Squamous cell carcinoma (96.6%) was dominant. Regarding clinical features of HNC, the percentage of
stage III cancer (54.54%) and moderately differentiated tumour (82.64%) was the highest. Among TNM classification, T3-4, N0 and M0 were more frequent. Conclusion: Smoking may be a key risk factor for HNC in addicts.